huda zoghbi lab

In her career, Zoghbi faced many obstacles. Our analysis of SCA1 transgenic mice revealed that the mutant protein aggregates in the nuclei of cerebellar Purkinje cells and that these aggregates stain positively for ubiquitin, the proteasome, and some chaperones. Huda Yahya Zoghbi (Arabic: هدى الهبري الزغبي Hudā al-Hibrī az-Zughbī; born 1954), born Huda El-Hibri, is a Lebanese-born American geneticist, and a professor at the Department of Molecular and Human Genetics, Baylor College of Medicine. However, she would not allow it. UTD Green Fellow. The laboratory uses genetic, biochemical, and cell biological approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases and Rett syndrome, and to study genes essential for normal neurodevelopment. Baylor College of Medicine will be closed on Monday, Jan. 18 in observance of Martin Luther King, Jr. Day. Heading. 713–798–8728 . Contact. Females may present with isolated mental retardation, autism, or milder forms of Rett if they have favorable X-chromosome inactivation. “I was encountering a lot of patients who had devastating neurological problems, and many of them were genetic,” she recalls. A new computational tool has been designed to make the life of bench scientists easier when it comes to identifying genes that are involved in particular diseases, an arduous and time consuming process. 713–798–6558. Our analysis of the cellular distribution of MeCP2 during development determined that MeCP2 is in mature neurons and that the number of MeCP2-positive cortical neurons increases up to 10 years of age in humans. Fall (Aug-Oct) 2019. Second, we found that the AXH domain in Ataxin-1 is a key mediator of the neuropathology in part through interactions with the transcriptional repressors Gfi-1 and Capicua. The glutamine tract seems to mediate its toxicity by modulating the activity of the AXH domain. © 2019 Huda Zoghbi Lab and Zhandong Liu Lab, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital1250 Moursund St., Houston, TX This finding suggested that the symptoms of Rett syndrome were caused by a defect in the function of MECP2: controlling the activity of other genes. The finding that Mecp2308 mice have altered RNA-splicing patterns in the cerebral cortex that are significantly different from these of wild-type animals led us to propose that MeCP2 acts as repressor, but when it is released from the promoter region, it participates in its second function as a splicing regulator of the newly transcribed genes. In her laboratory at Baylor College of Medicine, Dr. Huda Zoghbi and her colleagues have found two neuronal lineages in the hindbrain that act as ‘conductors’ of an exquisite biological symphony. Find out why.Get to Know Houston. Huda Zoghbi: I was really intrigued by one thing about this syndrome — the girls are healthy and look healthy when they’re born and achieve certain milestones, and then they lose those acquired skills.And we know that it’s not degenerative because they can live into adulthood. Huda Zoghbi’s experience diagnosing patients with Rett syndrome motivated her scientific research. 2016 Oct 25;5. pii: e19809. Dr. Huda Zoghbi is the Ralph D. Feigin professor at Baylor College of Medicine, an investigator at the Howard Hughes Medical Institute, and the director of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. Male Mecp2308 mice appear normal up to six weeks of age, when they develop tremors, seizures, coordination problems, social behavior abnormalities, and forepaw stereotypies similar to the hand-wringing seen in patients. Outdoors, the Lebanese civil war raged, making daily trips between home and lectures too dangerous. 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